Emergency Vets

Therapeutic Apheresis

Therapeutic Apheresis Machine

North Shore Veterinary Emergency and Critical Care Centre is proud to present Therapeutic Apheresis for your pet!

Veterinary Excellence

What is Therapeutic Apheresis?

Vet and Dog

Therapeutic Apheresis is a process of selectively removing blood components (plasma, RBCs, WBCs, and platelets) from continuously flowing blood by centrifugation.

Therapeutic Plasma Exchange (TPE) is the procedure to remove pathologic substances (generally pathologic antibodies and exogenous toxins) from patients with immune-mediated or autoimmune diseases, drug overdosage or poisoning.

Plasma Adsorption selectively removes exogenous poisons, drugs, or endogenous substances (cytokines, cholesterol) which are not removable by haemodialysis.

Leukapheresis selectively removes abnormal RBCs and malignant leukocytes. Alternatively, healthy components of the buffy coat (platelets, lymphocytes, stem cells, granulocytes) are harvested for selective processing and re-infused for immunotherapy or transplantation.

Your pet's aperesis procedure

Sean Johnson and white dog

WHAT TO EXPECT: A qualified veterinary surgeon and nursing team in TPE are responsible for operating and monitoring your pet throughout the procedure.

CONNECT: Under sedation, a central intravenous catheter is connected to your pet’s vein via their jugular for the procedure.


A small portion of your pet’s blood is removed and mixed with a fluid that prevents the blood from clotting. Most of your pet’s plasma is separated and removed from the other parts of their blood. The remaining parts of your pet’s blood are mixed with the new replacement plasma and then returned to your pet. After the procedure, your pet is awakened, monitored and given cage rest to aid their recovery.

Indications for Therapeutic Plasma Exchange (TPE)

Metabolic Diseases

Hematologic Diseases

Kidney Diseases


Immune-mediated hemolytic anemia

Therapeutic plasma exchange at (NSVECC) North Shore Veterinary Emergency and Critical Care

Pre treatment

Post Treatment

Effects of a single (3-hour) TPE treatment to correct severe in-saline agglutination in a dog with IMHA, Immunie-mediated hemolytic anemia.

Therapeutic Plasma Exchange should be considered as a FIRST LINE treatment for severe IMHA.